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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 39.09
Human Site: S905 Identified Species: 53.75
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S905 R Q A A R L F S V P H V V Q Q
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S905 R Q A A R L F S V P H V V Q Q
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S1026 R Q A A R L F S V P H V V Q Q
Dog Lupus familis XP_543550 1017 111618 S905 R Q A A R L F S V P H V V Q Q
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 S903 R Q A A R L F S V P H V V Q Q
Rat Rattus norvegicus NP_001129232 1015 111665 S903 R Q A A R L F S V P H V V Q Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S911 R Q A A R L F S M P H L V Q Q
Frog Xenopus laevis Q8QFR2 1013 112021 T901 R Q A A H L F T M P H L V Q K
Zebra Danio Brachydanio rerio XP_696478 1010 111223 S898 R L A S R L S S T P H H L Q Q
Tiger Blowfish Takifugu rubipres O42611 1025 111838 S913 R L A S R L S S T P H H L Q Q
Fruit Fly Dros. melanogaster O17468 1047 113397 V923 A T A V A A A V V A G S R M A
Honey Bee Apis mellifera XP_001122939 838 91355 K744 E Q Q L L A S K A L G S A Q E
Nematode Worm Caenorhab. elegans Q09589 935 103412 Q841 V K A V K E S Q L E Q L L H C
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 L870 R E A D E S R L R E V C E S F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 S926 A S S D T N L S W D P Y V L G
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 H746 I P K I C L G H K V I K M V T
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 D904 V K A L L A R D G F E N F E S
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 86.6 66.6 60 60 13.3 13.3 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 93.3 73.3 73.3 13.3 20 40 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 13.3 N.A. 13.3 6.6 6.6
P-Site Similarity: N.A. 20 N.A. 20 13.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 83 48 6 18 6 0 6 6 0 0 6 0 6 % A
% Cys: 0 0 0 0 6 0 0 0 0 0 0 6 0 0 6 % C
% Asp: 0 0 0 12 0 0 0 6 0 6 0 0 0 0 0 % D
% Glu: 6 6 0 0 6 6 0 0 0 12 6 0 6 6 6 % E
% Phe: 0 0 0 0 0 0 48 0 0 6 0 0 6 0 6 % F
% Gly: 0 0 0 0 0 0 6 0 6 0 12 0 0 0 6 % G
% His: 0 0 0 0 6 0 0 6 0 0 59 12 0 6 0 % H
% Ile: 6 0 0 6 0 0 0 0 0 0 6 0 0 0 0 % I
% Lys: 0 12 6 0 6 0 0 6 6 0 0 6 0 0 6 % K
% Leu: 0 12 0 12 12 65 6 6 6 6 0 18 18 6 0 % L
% Met: 0 0 0 0 0 0 0 0 12 0 0 0 6 6 0 % M
% Asn: 0 0 0 0 0 6 0 0 0 0 0 6 0 0 0 % N
% Pro: 0 6 0 0 0 0 0 0 0 59 6 0 0 0 0 % P
% Gln: 0 53 6 0 0 0 0 6 0 0 6 0 0 65 53 % Q
% Arg: 65 0 0 0 53 0 12 0 6 0 0 0 6 0 0 % R
% Ser: 0 6 6 12 0 6 24 59 0 0 0 12 0 6 6 % S
% Thr: 0 6 0 0 6 0 0 6 12 0 0 0 0 0 6 % T
% Val: 12 0 0 12 0 0 0 6 42 6 6 36 53 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _